Extracting knowledge from the p53 mutation database: the influence of tabagism in the somatic mutations profile of lung cancer subjects

This work analyses a p53 mutation database aiming to unveil whether of not tabagism can influence the mutation profile of lung cancer patients. We analyzed both the frequency of single nucleotide mutations and the frequency of site (exon) mutations. For the database used, we conclude that tabagism produces more dramatic and unexpected mutations in the DNA sequence of p53.